Highly accurate protein structure prediction for the human proteome
Kathryn Tunyasuvunakool, Jonas Adler, Zachary Wu et al.
2021 · Nature · 3,192 citations
Abstract Protein structures can provide invaluable information, both for reasoning about biological processes and for enabling interventions such as structure-based drug development or targeted mutagenesis. After decades of effort, 17% of the total residues in human protein sequences are covered by an experimentally determined structure 1 . Here we markedly expand the structural coverage of the proteome by applying the state-of-the-art machine learning method, AlphaFold 2 , at a scale that covers almost the entire human proteome (98.5% of human proteins). The resulting dataset covers 58% of r…
Explore this paper's citation graph on Constellation.