Single-cell genomics: coming of age
Sten Linnarsson, Sarah Amalia Teichmann
2016 · Genome biology · 119 citations
Single-cell genomics is the study of the individuality of cells using omics approaches. Although young, the field has now entered its teenage years and is beginning to show clear signs of maturity. Its origins can be traced back to pioneering experiments that allowed the detection of gene expression in single cells by microarrays (reviewed in [1]). However, it was with the emergence of “next-generation” DNA sequencing that single-cell genomics really took off [2–4]. Although initial experiments were modest in size and resulted in noisy and incomplete data, they immediately revealed the great…
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