Single-Cell Genomics Reveals Hundreds of Coexisting Subpopulations in Wild Prochlorococcus
Nadav Kashtan, Sara E. Roggensack, Sébastien Rodrigue et al.
2014 · Science · 565 citations
Extensive genomic diversity within coexisting members of a microbial species has been revealed through selected cultured isolates and metagenomic assemblies. Yet, the cell-by-cell genomic composition of wild uncultured populations of co-occurring cells is largely unknown. In this work, we applied large-scale single-cell genomics to study populations of the globally abundant marine cyanobacterium Prochlorococcus. We show that they are composed of hundreds of subpopulations with distinct "genomic backbones," each backbone consisting of a different set of core gene alleles linked to a small dist…
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