The Engineering of Gene Regulatory Networks
Mads Kærn, William J. Blake, James J. Collins
2003 · Annual Review of Biomedical Engineering · 189 citations
The rapid accumulation of genetic information and advancement of experimental techniques have opened a new frontier in biomedical engineering. With the availability of well-characterized components from natural gene networks, the stage has been set for the engineering of artificial gene regulatory networks with sophisticated computational and functional capabilities. In these efforts, the ability to construct, analyze, and interpret qualitative and quantitative models is becoming increasingly important. In this review, we consider the current state of gene network engineering from a combined…
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